Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Creator: Keaton, Jacob M. , Kamali, Zoha , Young, William J. , Lehtimäki, T , Raitakari, OT , Johnson, AD , Newton-Cheh, C , Brown, MJ , Dominiczak, AF , Sever, PJ , Poulter, N , Chambers, JC , Elosua, R , Traylor, Matthew , Siscovick, D , Esko, T , Metspalu, A , Strawbridge, RJ , Laakso, M , Hamsten, A , Hottenga, J-J , de Geus, E , Morris, AD , Palmer, CNA , Giri, Ayush , Nolte, IM , Milaneschi, Y , Marten, J , Wright, A , Zeggini, E , Howson, JMM , O'Donnell, CJ , Spector, T , Nalls, MA , Simonsick, EM , Zheng, Zhili , Liu, Y , van Duijn, CM , Butterworth, AS , Danesh, JN , Menni, C , Wareham, NJ , Khaw, K-T , Sun, YV , Wilson, PWF , Cho, K , Zeng, Jian , Visscher, PM , Denny, JC , Million Veteran Program, , Lifelines Cohort Study, , CHARGE consortium, , ICBP Consortium, , Levy, D , Edwards, TL , Munroe, PB , Snieder, H , Chasman, Daniel I. , Warren, HR , Morris, Andrew P. , Caulfield, Mark J. , Hwang, Shih-Jen , Kooner, Jaspal S. , Xie, Tian , Attia, John R. , Attia, JR , Morrison, AC , Loos, RJF , Kristiansson, K , Schmidt, R , Hicks, AA , Pramstaller, PP , Nelson, CP , Samani, NJ , Vaez, Ahmad , Risch, L , Gyllensten, U , Melander, O , Riese, H , Wilson, JF , Campbell, H , Rich, SS , Psaty, BM , Lu, Y , Rotter, JI , Williams, Ariel , Guo, X , Rice, KM , Vollenweider, P , Sundström, J , Langenberg, C , Tobin, MD , Giedraitis, V , Luan, J , Tuomilehto, J , Kutalik, Z , Goleva, Slavina B. , Ripatti, S , Salomaa, V , Girotto, G , Trompet, S , Jukema, JW , van der Harst, P , Ridker, PM , Giulianini, F , Vitart, V , Goel, A , Ani, Alireza , Watkins, H , Harris, SE , Deary, IJ , van der Most, PJ , Oldehinkel, AJ , Keavney, BD , Hayward, C , Campbell, A , Boehnke, M , Scott, LJ , Evangelou, Evangelos , Boutin, T , Mamasoula, C , Järvelin, M-R , Peters, A , Gieger, C , Lakatta, EG , Cucca, F , Hui, J , Knekt, P , Enroth, S , Hellwege, Jacklyn N. , De Borst, MH , Polašek, O , Concas, MP , Catamo, E , Cocca, M , Li-Gao, R , Hofer, E , Schmidt, H , Spedicati, B , Waldenberger, M , Yengo, Loic , Strachan, DP , Laan, M , Teumer, A , Dörr, M , Gudnason, V , Cook, JP , Ruggiero, D , Kolcic, I , Boerwinkle, E , Traglia, M
- Resource Type: journal article
- Date: 2024
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
- Creator: Shrine, Nick , Izquierdo, Abril G. , Hobbs, Brian D. , Foong, RE , Harris, SE , Taylor, A , Redmond, P , Cook, JP , Mahajan, A , Lind, L , Palviainen, T , Lehtimäki, T , Raitakari, OT , Moll, Matthew , Kaprio, J , Rantanen, T , Pietiläinen, KH , Cox, SR , Pennell, CE , Hall, GL , Gauderman, WJ , Brightling, C , Wilson, JF , Vasankari, T , Kim, Wonji , Laitinen, T , Salomaa, V , Mook-Kanamori, DO , Timpson, NJ , Zeggini, E , Dupuis, J , Hayward, C , Brumpton, B , Langenberg, C , Weiss, S , Tal-Singer, Ruth , Homuth, G , Schmidt, CO , Probst-Hensch, N , Jarvelin, M-R , Morrison, AC , Polasek, O , Rudan, I , Lee, J-H , Sayers, I , Rawlins, EL , Bakke, Per , Dudbridge, F , Silverman, EK , Strachan, DP , Walters, RG , Morris, AP , London, SJ , Cho, MH , Wain, LV , Hall, IP , Tobin, MD , Fawcett, Katherine A. , John, Catherine , Coley, Kayesha , Piga, Noemi Nicole , Pozarickij, Alfred , Chen, Jing , Wang, Carol A. , Pennell, Craig E. , Chen, Z , Li, L , China Kadoorie Biobank Collaborative Group, , Wijnant, SRA , Lahousse, L , Brusselle, G , Uitterlinden, AG , Manichaikul, A , Packer, Richard , Oelsner, EC , Rich, SS , Barr, RG , Kerr, SM , Vitart, V , Brown, MR , Wielscher, M , Imboden, M , Jeong, A , Bartz, TM , Hall, Robert J. , Gharib, SA , Flexeder, C , Karrasch, S , Gieger, C , Peters, A , Stubbe, B , Hu, X , Ortega, VE , Meyers, DA , Bleecker, ER , Guyatt, Anna L. , Gabriel, SB , Gupta, N , Smith, AV , Luan, J , Zhao, J-H , Hansen, AF , Langhammer, A , Willer, C , Bhatta, L , Porteous, D , Batini, Chiara , Smith, BH , Campbell, A , Sofer, T , Lee, J , Daviglus, ML , Yu, B , Lim, E , Xu, H , O'Connor, GT , Thareja, G , Thompson, Rebecca J. , Albagha, OME , Qatar Genome Program Research (QGPR) Consortium, , Suhre, K , Granell, R , Faquih, TO , Hiemstra, PS , Slats, AM , Mullin, BH , Hui, J , James, A , Pavuluri, Chandan , Beilby, J , Patasova, K , Hysi, P , Koskela, JT , Wyss, AB , Jin, J , Sikdar, S , Lee, M , May-Wilson, S , Pirastu, N , Malik, Vidhi , Kentistou, KA , Joshi, PK , Timmers, PRHJ , Williams, AT , Free, RC , Wang, X , Morrison, JL , Gilliland, FD , Wang, CA
- Resource Type: journal article
- Date: 2023
A Genome-Wide Association Study of Total Child Psychiatric Problems Scores
- Creator: Neumann, Alexander , Nolte, Ilja M. , Helmer, Quinta , Karhunen, Vile , Krapohl, Eva , Lu, Yi , van der Most, Peter J. , Palviainen, Teemu , St Pourcain, Beate , Seppälä, Ilkka , Suarez, Anna , Vilor-Tejedor, Natalia , Pappa, Irene , Tiesler, Carla M. T. , Wang, Carol , Wills, A , Zhou, A , Alemany, S , Bisgaard, H , Bønnelykke, K , Davies, GE , Hakulinen, C , Henders, AK , Ahluwalia, Tarunveer S. , Hyppönen, E , Stokholm, J , Bartels, M , Hottenga, J-J , Heinrich, J , Hewitt, J , Keltikangas-Järvinen, L , Korhonen, T , Kaprio, J , Lahti, J , Pettersson, Erik , Lahti-Pulkkinen, M , Lehtimäki, T , Middeldorp, CM , Najman, JM , Pennell, Craig , Power, C , Oldehinkel, AJ , Plomin, R , Räikkönen, K , Raitakari, OT , Rodriguez, Alina , Rimfeld, K , Sass, L , Snieder, H , Standl, M , Sunyer, J , Williams, GM , Bakermans-Kranenburg, MJ , Boomsma, DI , van IJzendoorn, MH , Hartman, CA , Whitehouse, Andrew , Tiemeier, H , van Beijsterveldt, Catharina E. M. , Benyamin, Beben , Hammerschlag, Anke R.
- Resource Type: journal article
- Date: 2022
Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms
- Creator: Jami, Eshim S. , Hammerschlag, Anke R. , Lu, Qing , Mallard, Travis T. , Mishra, Pashupati P. , Nolte, Ilja M. , Palviainen, Teemu , Peterson, Roseann E. , Sallis, Hannah M. , Shabalin, Andrey A. , Tate, Ashley E. , Thiering, Elisabeth , Ip, Hill F. , Vilor-Tejedor, Natàlia , Wang, Carol , Zhou, A , Adkins, DE , Alemany, S , Ask, H , Chen, Q , Corley, RP , Ehli, EA , Evans, LM , Allegrini, Andrea G. , Havdahl, A , Hagenbeek, FA , Hakulinen, C , Henders, AK , Hottenga, JJ , Korhonen, T , Mamun, A , Marrington, S , Neumann, A , Rimfeld, K , Benyamin, Beben , Rivadeneira, F , Silberg, JL , van Beijsterveldt, CE , Vuoksimaa, E , Whipp, AM , Tong, X , Andreassen, OA , Boomsma, DI , Brown, SA , Burt, SA , Border, Richard , Copeland, W , Dick, DM , Harden, KP , Harris, KM , Hartman, CA , Heinrich, J , Hewitt, JK , Hopfer, C , Hypponen, E , Jarvelin, M-R , Diemer, Elizabeth W. , Kaprio, J , Keltikangas-Järvinen, L , Klump, KL , Krauter, K , Kuja-Halkola, R , Larsson, H , Lehtimäki, T , Lichtenstein, P , Lundström, S , Maes, HH , Jiang, Chang , Magnus, P , Munafò, MR , Najman, JM , Njølstad, PR , Oldehinkel, AJ , Pennell, CE , Plomin, R , Reichborn-Kjennerud, T , Reynolds, C , Rose, RJ , Karhunen, Ville , Smolen, A , Snieder, H , Stallings, M , Standl, M , Sunyer, J , Tiemeier, H , Wadsworth, SJ , Wall, TL , Whitehouse, AJO , Williams, GM , Lu, Yi , Ystrøm, E , Nivard, MG , Bartels, M , Middeldorp, CM
- Resource Type: journal article
- Date: 2022
Variants associated with HHIP expression have sexdifferential effects on lung function
- Creator: Fawcett, Katherine A. , Obeidat, Ma'en , Melbourne, Carl A. , Shrine, Nick , Guyatt, Anna L. , John, Catherine , Luan, Jian'an , Richmond, Anne , Moksnes, Marta R. , Granell, Raquel , Weiss, Stefan , Imboden, Medea , May-Wilson, Sebastian , Hysi, Pirro , Boutin, Thibaud S. , Portas, Laura , Flexeder, Claudia , Harris, Sarah E. , Wang, Carol A. , Lyytikäinen, Leo-Pekka , Pennell, Craig E. , Palviainen, Teemu , Foong, RE , Keidel, D , Minelli, C , Langenberg, C , Bossé, Y , Berge, MVD , Sin, DD , Hao, K , Campbell, A , Porteous, D , Padmanabhan, S , Smith, BH , Evans, DM , Ring, S , Langhammer, A , Hveem, K , Willer, C , Ewert, R , Stubbe, B , Pirastu, N , Klaric, L , Joshi, PK , Patasova, K , Massimo, M , Polasek, O , Starr, JM , Karrasch, S , Strauch, K , Meitinger, T , Rudan, I , Rantanen, T , Pietiläinen, K , Kähönen, M , Raitakari, OT , Hall, GL , Sly, PD , Kaprio, J , Lehtimäki, T , Vitart, V , Deary, IJ , Jarvis, D , Wilson, JF , Spector, T , Probst-Hensch, N , Wareham, NJ , Völzke, H , Henderson, J , Strachan, DP , Brumpton, BM , Hayward, C , Hall, IP , Tobin, MD , Wain, LV
- Resource Type: journal article
- Date: 2021
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
- Creator: Zheng, Yan , Huang, Tao , Tai, E-Shyong , Koh, Woon-Puay , Dorajoo, Rajkumar , Saw, Seang-Mei , Sabanayagam, Charumathi , Wong, Tien Yin , Gupta, Preeti , Rossing, Peter , Ahluwalia, Tarunveer S. , Vinding, Rebecca K. , Wang, Tiange , Bisgaard, H , Bønnelykke, K , Wang, Y , Graff, M , Voortman, T , van Rooij, FJA , Hofman, A , van Heemst, D , Noordam, R , Estampador, AC , Mei, Zhendong , Varga, TV , Enzenbach, C , Scholz, M , Thiery, J , Burkhardt, R , Orho-Melander, M , Schulz, CA , Ericson, U , Sonestedt, E , Kubo, M , Sun, Zhonghan , Akiyama, M , Zhou, A , Kilpeläinen, TO , Hansen, T , Kleber, ME , Delgado, G , McCarthy, M , Lemaitre, RN , Felix, JF , Jaddoe, VWV , Zhang, Tao , Wu, Y , Mohlke, KL , Lehtimäki, T , Wang, Carol A. , Pennell, CE , Schunkert, H , Kessler, T , Zeng, L , Willenborg, C , Peters, A , Ellervik, Christina , Lieb, W , Grote, V , Rzehak, P , Koletzko, B , Erdmann, J , Munz, M , Wu, T , He, M , Yu, C , Lecoeur, C , Chai, Jin-Fang , Froguel, P , Corella, D , Moreno, LA , Lai, CQ , Pitkänen, N , Boreham, CA , Ridker, PM , Rosendaal, FR , de Mutsert, R , Power, C , Sim, Xueling , Paternoster, L , Sørensen, TIA , Tjønneland, A , Overvad, K , Djousse, L , Rivadeneira, F , Lee, NR , Raitakari, OT , Kähönen, M , Viikari, J , van Dam, Rob M. , Langhendries, JP , Escribano, J , Verduci, E , Dedoussis, G , König, I , Balkau, B , Coltell, O , Dallongeville, J , Meirhaeghe, A , Amouyel, P
- Resource Type: journal article
- Date: 2020
A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity
- Creator: Bradfield, Jonathan P. , Vogelezang, Suzanne , Felix, Janine F. , Chesi, Alessandra , Helgeland, Øyvind , Horikoshi, Momoko , Karhunen, Ville , Lowry, Estelle , Cousminer, Diana L. , Ahluwalia, Tarunveer S. , Thiering, Elisabeth , Boh, Eileen T-H. , Zafarmand, Mohammad H. , Vilor-Tejedor, Natalia , Wang, Carol A. , Joro, Raimo , Chen, Zhanghua , Gauderman, William J. , Pitkänen, Niina , Parra, Esteban J. , Pennell, Craig E. , Fernandez-Rhodes, Lindsay , Alyass, A , Monnereau, C , Curtin, JA , Have, CT , McCormack, SE , Hollensted, M , Frithioff-Bøjsøe, C , Valladares-Salgado, A , Peralta-Romero, J , Teo, YY , Standl, M , Leinonen, JT , Holm, JC , Peters, T , Vioque, J , Vrijheid, M , Simpson, A , Custovic, A , Vaudel, M , Canouil, M , Lindi, V , Atalay, M , Kähönen, M , Raitakari, OT , van Schaik, BDC , Berkowitz, RI , Cole, SA , Voruganti, VS , Wang, Y , Highland, HM , Comuzzie, AG , Butte, NF , Justice, AE , Gahagan, S , Blanco, E , Lehtimäki, T , Lakka, TA , Hebebrand, J , Bonnefond, A , Grarup, N , Froguel, P , Lyytikäinen, LP , Cruz, M , Kobes, S , Hanson, RL , Zemel, BS , Hinney, A , Teo, KK , Meyre, D , North, KE , Gilliland, FD , Bisgaard, H , Bustamante, M , Bonnelykke, K , Rivadeneira, F , Uitterlinden, AG , Baier, LJ , Vrijkotte, TGM , Heinrich, J , Sørensen, TIA , Saw, SM , Pedersen, O , Hansen, T , Eriksson, J , Widén, E , McCarthy, MI , Njølstad, PR , Power, C , Hyppönen, E , Sebert, S , Brown, CD , Järvelin, MR , Timpson, NJ , Johansson, S , Hakonarson, H , Jaddoe, VWV
- Resource Type: journal article
- Date: 2019
Dairy intake and body composition and cardiometabolic traits among adults: mendelian randomization analysis of 182041 individuals from 18 studies
- Creator: Huang, Tao , Sun, Dianjianyi , Graff, Mariaelisa , Smith, Caren E. , Varbo, Anette , Lemaitre, Rozenn N. , Corella, Dolores , Wang, Carol A. , Tjønneland, Anne , Overvad, Kim , Sørensen, Thorkild I. A. , Feitosa, Mary F. , Heianza, Yoriko , Wojczynski, Mary K. , Kähönen, M , Mikkilä, V , Bartz, TM , Psaty, BM , Siscovick, DS , Danning, RD , Dedoussis, G , Pedersen, O , Hansen, T , Bergholdt, Helle K. M. , Havulinna, AS , Männistö, S , Rotter, JI , Sares-Jäske, L , Allison, MA , Rich, SS , Sorlí, JV , Coltell, O , Pennell, CE , Eastwood, P , Gao, Meng , Ridker, PM , Viikari, J , Raitakari, O , Lehtimäki, T , Helminen, M , Wang, Y , Deloukas, P , Knekt, P , Kanerva, N , Kilpeläinen, TO , Fang, Zhe , Province, MA , Mozaffarian, D , Chasman, DI , Nordestgaard, BG , Ellervik, C , Qi, L , Ding, Ming , Frazier-Wood, Alexis C. , North, Kari E. , Marouli, Eirini
- Resource Type: journal article
- Date: 2019
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
- Creator: Karlsson Linnér, Richard , Kalnapenkis, A , Kasela, S , Kettunen, J , Kim, Y , Kirsten, H , Kovacs, P , Krohn, K , Kronberg-Guzman, J , Kukushkina, V , Kutalik, Z , Lee, B , Lehtimäki, T , Loeffler, M , Marigorta, UM , Metspalu, A , Milani, L , Montgomery, GW , Müller-Nurasyid, M , Nauck, M , Penninx, B , Perola, M , Biroli, Poetro , Nivard, Michel G. , Okbay, Aysu , Rietveld, Cornelius A. , Timshel, Pascal N. , Trzaskowski, Maciej , de Vlaming, Ronald , Zünd, Christian L. , Bao, Yanchun , Buzdugan, Laura , Caplin, Ann H. , Kong, Edward , Chen, Chia-Yen , Eibich, P , Fontanillas, P , Gonzalez, JR , Joshi, PK , Karhunen, V , Kleinman, A , Levin, RZ , Lill, CM , Meddens, GA , Meddens, S. Fleur W. , Muntané, G , Sanchez-Roige, S , Rooij, FJV , Taskesen, E , Wu, Y , Zhang, F , Agee, M , Alipanahi, B , Bell, RK , Bryc, K , Wedow, Robbee , Elson, SL , Furlotte, NA , Huber, KE , Litterman, NK , McCreight, JC , McIntyre, MH , Mountain, JL , Northover, CAM , Pitts, SJ , Sathirapongsasuti, JF , Fontana, Mark Alan , Sazonova, OV , Shelton, JF , Shringarpure, S , Tian, C , Tung, JY , Vacic, V , Wilson, CH , Agbessi, M , Ahsan, H , Alves, I , Lebreton, Maël , Andiappan, A , Awadalla, P , Battle, A , Beutner, F , Jan Bonder, M , Boomsma, DI , Christiansen, M , Claringbould, A , Deelen, P , Esko, T , Tino, Stephen P. , Favé, MJ , Franke, L , Frayling, T , Gharib, SA , Gibson, G , Oldmeadow, Christopher , Holliday, Elizabeth G. , Scott, Rodney J. , Attia, John R. , Abdellaoui, Abdel , Hammerschlag, Anke R.
- Resource Type: journal article
- Date: 2019
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
- Creator: Merino, Jordi , Dashti, Hassan S. , Wojczynski, Mary K. , Männistö, Satu , Ngwa, Julius S. , Kho, Minjung , Ahluwalia, Tarunveer , Pervjakova, Natalia , Houston, Denise K. , Bouchard, Claude , Huang, Tao , Orho-Melander, Marju , Li, Sherly X. , Pennell, Craig E. , Wang, Carol A. , Pérusse, L , Pennell, CE , de Vries, PS , Voortman, T , Li, O , Kanoni, S , Rose, LM , Lehtimäki, T , Sarnowski, Chloé , Zhao, JH , Feitosa, MF , Luan, J , McKeown, NM , Smith, JA , Hansen, T , Eklund, N , Nalls, MA , Rankinen, T , Huang, J , Justice, Anne E. , Hernandez, DG , Schulz, CA , Manichaikul, A , Li-Gao, R , Vohl, MC , Wang, CA , van Rooij, FJA , Shin, J , Kalafati, IP , Day, F , Graff, Misa , Ridker, PM , Kähönen, M , Siscovick, DS , Langenberg, C , Zhao, W , Astrup, A , Knekt, P , Garcia, M , Rao, DC , Qi, Q , Papoutsakis, Constantina , Ferrucci, L , Ericson, U , Blangero, J , Hofman, A , Pausova, Z , Mikkilä, V , Wareham, NJ , Kardia, SLR , Pedersen, O , Jula, A , Smith, Caren E. , Curran, JE , Zillikens, MC , Viikari, JS , Forouhi, NG , Ordovás, JM , Lieske, JC , Rissanen, H , Uitterlinden, AG , Raitakari, OT , Kiefte-de Jong, JC , Dedoussis, George V. , Dupuis, J , Rotter, JI , North, KE , Scott, RA , Province, MA , Perola, M , Cupples, LA , Turner, ST , Sørensen, TIA , Salomaa, V , Lemaitre, Rozenn N. , Liu, Y , Sung, YJ , Qi, L , Bandinelli, S , Rich, SS , de Mutsert, R , Tremblay, A , Oddy, WH , Franco, OH , Paus, T
- Resource Type: journal article
- Date: 2019